Hydrochloric Acid → HCID 69252350, compound

HRID 902619Notes

Reaction equation

HRID 902619 reaction equation
[Cl:1][C:2]1[C:35]([C:36]([F:39])([F:38])[F:37])=[CH:34][CH:33]=[CH:32][C:3]=1[CH2:4][N:5]([CH2:20][CH:21]([O:28][C:29](=[O:31])[CH3:30])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[C:12]([CH2:16][C:17]([OH:19])=[O:18])[CH:13]=[CH:14][CH:15]=1.Cl>C(OCC)C>[ClH:1].[Cl:1][C:2]1[C:35]([C:36]([F:37])([F:38])[F:39])=[CH:34][CH:33]=[CH:32][C:3]=1[CH2:4][N:5]([CH2:20][CH:21]([O:28][C:29](=[O:31])[CH3:30])[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[C:12]([CH2:16][C:17]([OH:19])=[O:18])[CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10196601HCID 10196601, compound

Product 1

HCID 69252350HCID 69252350, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of 2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2-acetoxy-2-phenyl-ethyl)amino]propoxy}-phenyl)acetic acid in ethyl ether was added HCl in diethyl ether (1.0M). The suspension was filtered and dried to give the title compound as a white solid (99%). NMR(400 MHz, CD3OD) δ: 7.8 (m, 3H), 7.3 (s, 5H), 7.1 (t, J=4.0 Hz, 1H), 6.7 (m, 3H), 6.1 (m, 1H), 4.0 (m, 2H), 3.6-3.4 (m, 7H), 2.2 (m, 2H), 1.9 (s, 3H), 1.1 (t, J=4.2 Hz, 2H).

Workup

  1. filtrationThe suspension was filtered
  2. customdried

Sources & evidence

ORD record
ord-41cc8ada101e46c7b068c29a0980766b
Source dataset
uspto-grants-2008_04
Patent number
US07365085B2

Reaction notes

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