反应详情

A mixture of 4-(3-Methoxy-phenyl)-piperidine (0.8 g, 4.2 mmol), methylbromoacetate (1.28 g, 8.38 mmol), diisopropylethylamine (3.7 mL, 21 mmol) and MeOH (40 mL) was refluxed for 3 h. The reaction mixture was concentrated in vacuo, and the residue was partitioned between water and EtOAc and extracted. The organic layer was washed with water, brine, dried and concentrated in vacuo to give the title compound as an oil (1.0 g, 91% yield). MS(ESI) 264.2 (M+H+)

1. temperaturewas refluxed for 3 h
2. concentrationThe reaction mixture was concentrated in vacuo
3. customthe residue was partitioned between water and EtOAc
4. extractionextracted
5. washThe organic layer was washed with water, brine
6. customdried
7. concentrationconcentrated in vacuo