Hydrochloric Acid → 2-(Thiophen-2-yl)propanal

Temperature

0 °C

To a solution of diethylisocyanomethylphosphonate in diethyl ether (40 ml) was added butyl lithium (6.9 ml, 1.6M in hexane) dropwise at −60° C. After the reaction mixture was stirred at −60° C. for additional 15 min a solution of 2-acetylthiophene (1.26 g, 10 mmol) in diethyl ether (10 ml) was added at the same temperature. The reaction mixture was warmed up to 0° C. and was stirred for 1.5 h. Concentrated HCl (15 ml) was added at 0° C. and then ice bath was removed. After the resulting mixture was stirred at room temperature overnight it was poured to cold water (20 ml). The organic layer was washed with water, sat. sodium bicarbonate, brine, dried over sodium sulfate and concentrated. The crude product was used in the next step without purification.

1. additionwas added at the same temperature
2. customice bath was removed
3. stirringAfter the resulting mixture was stirred at room temperature overnight it
4. additionwas poured to cold water (20 ml)
5. washThe organic layer was washed with water, sat. sodium bicarbonate, brine
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated
8. customThe crude product was used in the next step without purification

ORD record

ord-a354f624994543cf870f2389f85f1198

Source dataset

uspto-grants-2008_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07365085B2