反应详情

A solution of 3-chloro-1-propanol (1.88 g, 20 mmole) in 20 ml of pyridine was treated at 0° with tosyl chloride (7.6 g, 40 mmole). The solution was warmed to 23°, and stirred 16 hours. The reaction was diluted with 100 mL of H2O and stirred for 90 minutes, and extracted with Et2O. The extracts were washed with 1N HCl, dried, and the solvents thoroughly removed, and gave the titled product, 2.3 g (46%). MS (ESI) 188 (MH+).

1. temperatureThe solution was warmed to 23°
2. stirringstirred for 90 minutes
3. extractionextracted with Et2O
4. washThe extracts were washed with 1N HCl
5. customdried
6. customthe solvents thoroughly removed