Trifluoroacetic acid → HCID 67056716, compound

HRID 902903Notes

Reaction equation

HRID 902903 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([NH:13][C@H:14]1[CH2:19][CH2:18][C@H:17]([C:20]([N:22]([CH3:24])[CH3:23])=[O:21])[CH2:16][C@H:15]1[NH:25][C:26]([C:28]1[N:29]=[CH:30][C:31]3[CH2:36][N:35]([C:37](OC(C)(C)C)=O)[CH2:34][C:32]=3[N:33]=1)=[O:27])=[O:12])=[CH:5]2.FC(F)(F)C(O)=O>C(Cl)Cl>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([NH:13][C@H:14]1[CH2:19][CH2:18][C@H:17]([C:20]([N:22]([CH3:24])[CH3:23])=[O:21])[CH2:16][C@H:15]1[NH:25][C:26]([C:28]1[N:29]=[CH:30][C:31]3[CH2:36][N:35]([CH3:37])[CH2:34][C:32]=3[N:33]=1)=[O:27])=[O:12])=[CH:5]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59677040HCID 59677040, compound

Product 1

HCID 67056716HCID 67056716, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound (367 mg) obtained in Example 237 was dissolved in methylene chloride (10 ml), and trifluoroacetic acid (10 ml) was added to stir the mixture at room temperature for 2 hours. The reaction mixture was dried to solid under reduced pressure. The title compound was obtained from the thus-obtained crude product and formalin in a similar manner to the process described in Example 18.

Workup

  1. customThe reaction mixture was dried to solid under reduced pressure

Sources & evidence

ORD record
ord-0cf1445f16304161b1e13425cf71c2c2
Source dataset
uspto-grants-2008_04
Patent number
US07365205B2

Reaction notes

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