反应详情

4.8 g of 1B was reduced with hydrogen in a Parr shaker (Raney nickel catalyst, tetrahydrofuran solvent, 50 p.s.i.g. hydrogen). A solution of the resulting aniline in ethyl acetate was treated with an excess of phosgene (5 hours at reflux). A solution of the resulting isocyanate in tetrahydrofuran was treated with 3.5 g of 3C (12 hours, room temperature). The resulting crude product was purified by silica gel chromatography to give 3, as a white solid, mp: 133°-135° C.

1. customThe resulting crude product was purified by silica gel chromatography
2. customto give 3