Hydrochloric Acid → HCID 15313948, compound

HRID 903116Notes

Reaction equation

HRID 903116 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][CH:13]([CH:17]([CH3:19])[CH3:18])[C:14](N)=[O:15].Cl.[C:21](=O)(O)[O-:22].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][CH:13]([CH:17]([CH3:19])[CH3:18])[C:14]([O:22][CH3:21])=[O:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 233376972-(2-Chloro-4-trifluoromethylphenylamino)-3-methylbutyramide

Product 1

HCID 15313948HCID 15313948, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutyramide (1 mmol) and 4 ml of methanol, saturated with HCl gas, is heated at 75° for about 40 hours. The mixture is cooled, poured into saturated aqueous sodium bicarbonate and extracted with ether. The combined ether extracts are dried over sodium sulfate and solvent removed in vacuo to yield methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, which can be further purified by prep. thin layer chromatography.

Workup

  1. temperatureThe mixture is cooled
  2. extractionextracted with ether
  3. dry with materialThe combined ether extracts are dried over sodium sulfate and solvent
  4. customremoved in vacuo

Sources & evidence

ORD record
ord-4eef25e6ba7e4adaa88d56cebb91a18c
Source dataset
uspto-grants-1980_10
Patent number
US04226802

Reaction notes

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