Sodium Bicarbonate → HCID 23338131, compound

HRID 903316Notes

Reaction equation

HRID 903316 reaction equation
C(=O)(O)[O-].[Na+].Cl.[NH2:7][CH2:8][C:9]#[C:10][CH2:11][OH:12].[CH:13]1([CH3:25])[CH2:18][CH2:17][CH:16]([CH:19]([CH3:21])[CH3:20])[CH:15]([C:22](Cl)=[O:23])[CH2:14]1>O.CCOCC>[OH:12][CH2:11][C:10]#[C:9][CH2:8][NH:7][C:22]([CH:15]1[CH:16]([CH:19]([CH3:21])[CH3:20])[CH2:17][CH2:18][CH:13]([CH3:25])[CH2:14]1)=[O:23]

Participants

6

Reactant 3

HCID 516892Sodium BicarbonateHCID 13734319Cyclohexanecarbonyl chloride, 5-methyl-2-(1-methylethyl)-HCID 197755314-Aminobut-2-yn-1-ol hydrochloride

Product 1

HCID 23338131HCID 23338131, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent

Procedure

Sodium bicarbonate (2.5 g.) and 4-aminobut-2-yn-1-ol hydrochloride (2.5 g.) were dissolved in water (60 ml.) and a solution of p-menth-3-oyl chloride in ether (100 ml.) added. The mixture was stirred vigorously for two hours and the ether layer separated and dried over MgSO4. Evaporation of the ether gave N-(4-hydroxybut-2-ynyl)-p-menthane-3-carboxamide as a very viscous liquid: b.p. 180°/0.1 mm.

Workup

  1. customthe ether layer separated
  2. dry with materialdried over MgSO4
  3. customEvaporation of the ether

Sources & evidence

ORD record
ord-e4b4a08453fc4b79b9d8a36a715ddc74
Source dataset
uspto-grants-1980_10
Patent number
US04226988

Reaction notes

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