HCID 12823194, compound → HCID 23336598, compound

HRID 903566Notes

Reaction equation

HRID 903566 reaction equation
C([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[C:7]([SH:15])[C:8]([Cl:14])=[CH:9][CH:10]=2)[CH2:5]1)(=O)C>Cl>[ClH:14].[Cl:14][C:8]1[C:7]([SH:15])=[C:6]2[C:11]([CH2:12][CH2:13][NH:4][CH2:5]2)=[CH:10][CH:9]=1

Participants

3

Reactant 1

HCID 12823194HCID 12823194, compound

Product 1

HCID 23336598HCID 23336598, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A suspension of N-acetyl-7-chloro-8-mercapto-1,2,3,4-tetrahydroisoquinoline (1 g., 0.004 m.) in dilute hydrochloric acid was refluxed for three hours under an argon atmosphere. The reaction mixture was evaporated under reduced pressure and the residue was dried by evaporation from methanol-toluene. Recrystallization from methanol-ethyl acetate gave 7-chloro-8-mercapto-1,2,3,4-tetrahydroisoquinoline hydrochloride, m.p. 205°-207° C.

Workup

  1. temperaturewas refluxed for three hours under an argon atmosphere
  2. customThe reaction mixture was evaporated under reduced pressure
  3. dry with materialthe residue was dried by evaporation from methanol-toluene
  4. customRecrystallization from methanol-ethyl acetate

Sources & evidence

ORD record
ord-e2b0008836b34f51a5c354b5f9586ae0
Source dataset
uspto-grants-1980_10
Patent number
US04228170

Reaction notes

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