Isopropenyl acetate → HCID 23336543, compound

HRID 903572Notes

Reaction equation

HRID 903572 reaction equation
[NH2:1][C:2]1[C:11]([C:12]([F:15])([F:14])[F:13])=[C:10]2[C:5]([CH2:6][CH2:7][NH:8][CH2:9]2)=[CH:4][CH:3]=1.[C:16](OC(C)=C)(=[O:18])[CH3:17]>C(OCC)(=O)C>[C:16]([N:8]1[CH2:7][CH2:6][C:5]2[C:10](=[C:11]([C:12]([F:15])([F:13])[F:14])[C:2]([NH2:1])=[CH:3][CH:4]=2)[CH2:9]1)(=[O:18])[CH3:17]

Participants

4

Reactant 2

HCID 7916Isopropenyl acetateHCID 23336604HCID 23336604, compound

Product 1

HCID 23336543HCID 23336543, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

7-Amino-8-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline (8.7 g., 0.04 m.) is treated with isopropenyl acetate (8.0 g., 0.08 m.) in refluxing ethyl acetate to give N-acetyl-7-amino-8-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline.

Sources & evidence

ORD record
ord-7769aadac9f147d18b1439bcc881988a
Source dataset
uspto-grants-1980_10
Patent number
US04228170

Reaction notes

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