HCID 23335449, compound → HCID 131711917, compound

HRID 903883Notes

Reaction equation

HRID 903883 reaction equation
C([O:3][C:4]([CH:6]1[N:10]([C:11](=[S:21])[NH:12][C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[C:15]([Cl:20])[CH:14]=2)[CH2:9][CH2:8][S:7]1)=O)C>Cl>[Cl:20][C:15]1[CH:14]=[C:13]([N:12]2[C:4](=[O:3])[CH:6]3[S:7][CH2:8][CH2:9][N:10]3[C:11]2=[S:21])[CH:18]=[C:17]([Cl:19])[CH:16]=1

Participants

3

Reactant 1

HCID 23335449HCID 23335449, compound

Product 1

HCID 131711917HCID 131711917, compoundYield 74.7%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 2.19 g of the obtained 3-(3,5-dichlorophenylthiocarbamoyl)thiazolidine-2-carboxylic acid ethyl ester and 20 ml of concentrated hydrochloric acid was stirred at 120° C. for 1.5 hours. After the reaction mixture was cooled, the precipitate was separated, followed by recrystallization from a mixed solvent of ethyl acetate and n-hexane to give 1.43 g (yield 74.7%) of 6-(3,5-dichlorophenyl)perhydroimidazo[5,1-b]thiazole-5-thion-7-on (Compound No. 2). The resulting point and the elementary analysis were as given in table 1.

Workup

  1. temperatureAfter the reaction mixture was cooled
  2. customthe precipitate was separated
  3. customfollowed by recrystallization from a mixed solvent of ethyl acetate and n-hexane

Sources & evidence

ORD record
ord-74c4518c0a874b518b96a41493785772
Source dataset
uspto-grants-1980_10
Patent number
US04229461

Reaction notes

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