Ethanol → HCID 23335847, compound

HRID 904028Notes

Reaction equation

HRID 904028 reaction equation
Cl[S:2]([CH:5]([C:9]1[CH:10]=[CH:11][C:12]2[O:16][CH2:15][CH2:14][C:13]=2[CH:17]=1)[C:6]([OH:8])=[O:7])(=[O:4])=[O:3].[CH2:18]([OH:20])[CH3:19].C(N(CC)CC)C.O>C(OCC)C>[CH2:18]([O:20][S:2]([CH:5]([C:9]1[CH:10]=[CH:11][C:12]2[O:16][CH2:15][CH2:14][C:13]=2[CH:17]=1)[C:6]([OH:8])=[O:7])(=[O:3])=[O:4])[CH3:19]

Participants

6

Reactant 4

HCID 702EthanolHCID 962WaterHCID 8471TriethylamineHCID 23335839alpha-Chlorosulfonyl(2,3-dihydro-5-benzofuranyl)acetic acid

Product 1

HCID 23335847HCID 23335847, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Conditions

Temperature
20 °C

Procedure

α-Chlorosulfonyl(2,3-dihydro-5-benzofuranyl)acetic acid (5 mmole) is added to 30 ml of ethyl ether. To this mixture is added 5 mmole of ethanol in 10 ml of ethyl ether which contains 10 mmole of triethylamine. The mixture is stirred at 20° C. for about 1 hour and 50 ml of water is added. The pH is adjusted to about 6.5 and the layers separated. The organic layer is dried over magnesium sulfate, filtered and evaporated to give α-ethoxysulfonyl(2,3-dihydro-5-benzofuranyl)acetic acid.

Workup

  1. customthe layers separated
  2. dry with materialThe organic layer is dried over magnesium sulfate
  3. filtrationfiltered
  4. customevaporated

Sources & evidence

ORD record
ord-9d335cd22e5647139676fd2f35ab14c9
Source dataset
uspto-grants-1980_10
Patent number
US04229575

Reaction notes

Loading…