Imidazole → HCID 23333787, compound

HRID 904144Notes

Reaction equation

HRID 904144 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[C:10]([OH:11])=[CH:9][CH:8]=[C:7]([CH3:12])[N:6]=1)[CH3:3].[NH:13]1C=CN=[CH:14]1>C1(C)C(C)=CC=CC=1>[N:2]1([CH2:4][C:5]2[C:10]([OH:11])=[CH:9][CH:8]=[C:7]([CH3:12])[N:6]=2)[CH:1]=[CH:14][N:13]=[CH:3]1

Participants

4

Reactant 2

HCID 795ImidazoleHCID 233337942-[(Dimethylamino)methyl]-6-methyl-3-pyridinol

Product 1

HCID 23333787HCID 23333787, compoundYield 76.3%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

The procedure described in Example 1 was repeated except that 2-dimethylaminomethyl-3-hydroxy-6-methylpyridine (16.6 g.) and imidazole (6.8 g.) were reacted in xylene (50 ml.) to afford 2-(imidazol-1-ylmethyl)-3-hydroxy-6-methylpyridine (yield, 14.42 g.), m.p. 153°-155° C. after recrystallization from isopropanol/petroleum ether (b.p. 60°-80° C.).

Sources & evidence

ORD record
ord-06271c6cf729436fb963977e705f650a
Source dataset
uspto-grants-1980_10
Patent number
US04230714

Reaction notes

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