反应详情

温度

65 °C

To 3.0 g (26.5 mM) of creatinine in 50 ml of anhydrous DMF was added with stirring a solution of 4-chloro-2-thienyl isocyanate in 25 ml of toluene. After stirring at 65° C. for 5 hrs., the mixture was cooled, added to 200 ml of water and filtered to separate a precipitate, which was recrystallized from ethanol and then ethyl acetate to give 1.0 g of the above urea as a light tan solid, m.p. 203°-204° C. (dec.) containing 1/8 mole of ethyl acetate of recrystallization.

1. temperature, the mixture was cooled
2. filtrationfiltered
3. customto separate a precipitate, which
4. customwas recrystallized from ethanol