Hydrochloric Acid → HCID 70586442, compound

HRID 904207Notes

Reaction equation

HRID 904207 reaction equation
C([N:3]1[CH2:21][CH2:20][C@@:10]23[C:11]4[CH:12]=[C:13]([O:18][CH3:19])[CH:14]=[CH:15][C:16]=4[CH2:17][C@@H:4]1[C@@H:5]2[C@@H:6]([CH3:23])[CH2:7][C:8](=[O:22])[CH2:9]3)#N.[ClH:24]>>[ClH:24].[CH3:19][O:18][C:13]1[CH:14]=[CH:15][C:16]2[CH2:17][C@H:4]3[NH:3][CH2:21][CH2:20][C@@:10]4([C:11]=2[CH:12]=1)[C@H:5]3[C@@H:6]([CH3:23])[CH2:7][C:8](=[O:22])[CH2:9]4

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86737291HCID 86737291, compound

Product 1

HCID 70586442HCID 70586442, compound

Procedure

A suspension of 17-cyano-3-methoxy-8β-methylmorphinan-6-one (prepared in Part B) in 2 N HCl (1 g/30 ml) was refluxed for 8 hours. The resulting solution was evaporated to dryness, azeotroped several times with ethanol, and the crystalline residue suspended in ethanol and collected. The product was used without further purification. The yield of crystalline material, mp 204°-208° C., was 90%.

Workup

  1. temperaturewas refluxed for 8 hours
  2. customThe resulting solution was evaporated to dryness
  3. customazeotroped several times with ethanol
  4. customcollected
  5. customThe product was used without further purification

Sources & evidence

ORD record
ord-dc96c9edcf97413fb59f378940e43954
Source dataset
uspto-grants-1980_10
Patent number
US04230712

Reaction notes

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