Hydrochloric Acid → HCID 70585373, compound

HRID 904216Notes

Reaction equation

HRID 904216 reaction equation
C([N:3]1[CH2:21][CH2:20][C@@:10]23[C:11]4[CH:12]=[C:13]([O:18][CH3:19])[CH:14]=[CH:15][C:16]=4[CH2:17][C@@H:4]1[C@@H:5]2[CH2:6][CH2:7][C:8](=[O:22])[CH2:9]3)#N.[ClH:23]>>[ClH:23].[CH3:19][O:18][C:13]1[CH:14]=[CH:15][C:16]2[CH2:17][C@H:4]3[NH:3][CH2:21][CH2:20][C@@:10]4([C:11]=2[CH:12]=1)[C@H:5]3[CH2:6][CH2:7][C:8](=[O:22])[CH2:9]4

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 53912372HCID 53912372, compound

Product 1

HCID 70585373HCID 70585373, compound

Procedure

A suspension of 17-cyano-3-methoxymorphinan-6-one (6.9 g; prepared in Part B) in 200 ml of 2 N HCl was refluxed for 8 hours. The resulting solution was treated as in Example 1C to yield 5.2 g of crystalline product, mp 190°-200° C. An additional 0.9 g was obtained from the mother liquor. Total yield was 6.1 g (85%).

Workup

  1. temperaturewas refluxed for 8 hours
  2. additionThe resulting solution was treated as in Example 1C

Sources & evidence

ORD record
ord-5189b1ac933e45049cff9070d13d5a4d
Source dataset
uspto-grants-1980_10
Patent number
US04230712

Reaction notes

Loading…