反应详情

A solution 4.6 g. of 11-bromoundecanol and 1.6 g. of sodium cyanide in 40 ml. of dimethylformamide is heated at 80° C. for 18 hours, cooled, and poured into ice-water. The mixture is extracted with methylene chloride and the extract is dried over anhydrous magnesium sulfate. Evaporation of the solution affords 12-hydroxydodecanonitrile as a yellow oil.

1. temperaturecooled
2. extractionThe mixture is extracted with methylene chloride
3. dry with materialthe extract is dried over anhydrous magnesium sulfate
4. customEvaporation of the solution