Hydrochloric Acid → 2-Hydroxy-5-(trifluoromethyl)pyridine

Temperature

20 °C

To 2 cc of concentrated ammonium hydroxide was added 0.1 g of this new 5-trifluoromethyl-2-pyrone compound isolated in Example 4 and the mixture was stirred for 0.5 hours. The mixture was cooled to 20° C., 1 cc of 50% sodium hydroxide solution was added and the mixture then boiled for 5 minutes. The solution was cooled to 20° C., diluted with 5 cc of water and the pH adjusted to 4 with concentrated hydrochloric acid. The solution was extracted with diethyl ether (3×25 cc), and the extract was evaporated under reduced pressure to give 5-trifluoromethyl-2-pyridone, mp 142°-145°, as in Example 1.

1. waitthe mixture then boiled for 5 minutes
2. temperatureThe solution was cooled to 20° C.
3. extractionThe solution was extracted with diethyl ether (3×25 cc)
4. customthe extract was evaporated under reduced pressure

ORD record

ord-70e6d3050c864f2f8aebaca635a2c170

Source dataset

uspto-grants-1980_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04230864