反应详情

温度

95 °C

A mixture of 10-oxo-10H-pyrido[1,2-a]thieno[3,2-d]pyrimidine-7-carboxamide (1.4 g, 0.006 mol), p-toluenesulfonyl chloride (1.6 g, 0.008 mol), and pyridine (1.4 ml, 0.017 mol) in dimethylformamide (10 ml) is heated at 95° C. for 75 minutes. The mixture is cooled, diluted with water (5 ml) and stirred. The precipitate is filtered, washed with water, with ethanol and dried. Recrystallization from dimethylformamide gives the product (0.8 g.), mp 263°-264° C. (dec).

1. temperatureThe mixture is cooled
2. filtrationThe precipitate is filtered
3. washwashed with water, with ethanol
4. customdried
5. customRecrystallization from dimethylformamide
6. customgives the product (0.8 g.), mp 263°-264° C. (dec)