反应详情

8-Acetamido-5-quinolinesulfinic acid (10 g, 40 mmole), m-(bromomethyl)phenyl acetate (11 g, 44 mmole), excess sodium bicarbonate (5 g) and dry dimethylformamide (50 ml) were mixed and heated on the steam bath for 11/2 hours. The mixture was slowly poured into 800 ml stirred water and the mixture stirred another 30 min. The solid was filtered off, washed with water, and air-dried overnight. Yield 15.8 g (99 percent) of crude but relatively pure product, m.p. 179°-182° C. A sample recrystallized from toluene, melted 180°-182° C.

1. temperatureheated on the steam bath for 11/2 hours
2. additionThe mixture was slowly poured into 800 ml
3. filtrationThe solid was filtered off
4. washwashed with water
5. customair-dried overnight
6. customA sample recrystallized from toluene
7. custommelted 180°-182° C.