Phenyl Isothiocyanate → SBB042385

HRID 904743Notes

Reaction equation

HRID 904743 reaction equation
[C:1]1([N:7]=[C:8]=[S:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=1>C1C=CC=CC=1>[C:1]1([NH:7][C:8]([NH:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)=[S:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 7673Phenyl IsothiocyanateHCID 195092-Pyridinemethanamine

Product 1

HCID 737300SBB042385Yield 80%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

N-Phenyl-N'-2-pyridinylmethylthiourea is prepared by heating 19.8 g (0.147 m) phenylisothiocyanate and 13.2 g (0.122 m) 2-aminomethylpyridine in 500 ml benzene for 3 hr. The solid (22.8 g, 77% yield) which is collected with a melting point of 98°-9° C. and is analytically pure.

Sources & evidence

ORD record
ord-ad4ce3ddb61e48e3aecc53e21b159ec5
Source dataset
uspto-grants-1983_12
Patent number
US04419516

Reaction notes

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