反应详情

The procedure in Example 9, Part A, was followed in which 4a-(m-methoxyphenyl)-1,3-diketo-1,2,3,4,4a,5,6,7-octahydroisoquinoline (12 g, 0.05 moles) in 150 ml of anhydrous dimethylformamide was added to a 55% suspension of sodium hydride in mineral oil (2.4 g) in 100 ml of dimethylformamide at 70°; n-hexyl bromide (9.1 g) was added, the reaction heated at 70° for 18 hrs. The crude material obtained from this procedure was chromatographed to yield 12 g of product.

1. temperaturethe reaction heated at 70° for 18 hrs
2. customThe crude material obtained from this procedure
3. customwas chromatographed