反应详情

To 50 ml of 4 N hydrochloric acid containing 11.8 g of 2-amino-4-chloro-5-sulfamylaniline was added 9.2 g of hexanoic acid and the suspension refluxed for 6 hours. Concentration in vacuo provided a solid which was then slowly added with stirring to 100 ml of 38% ammonium hydroxide. After collecting the solid by filtration, the precipitate was added to 400 ml of methanol and the suspension brought to a boil. Charcoal was then added and the mixture filtered through filter paper, cooled, and filtered through Celite. Concentration in vacuo gave brown crystals which upon recrystallization from acetonitrile provided 2.6 g of product, mp 183°-185°.

1. temperaturethe suspension refluxed for 6 hours
2. concentrationConcentration in vacuo
3. customprovided a solid which
4. additionwas then slowly added
5. customAfter collecting the solid
6. filtrationby filtration
7. additionthe precipitate was added to 400 ml of methanol
8. additionCharcoal was then added
9. filtrationthe mixture filtered
10. filtrationthrough filter paper
11. temperaturecooled
12. filtrationfiltered through Celite
13. concentrationConcentration in vacuo
14. customgave brown crystals which
15. customupon recrystallization from acetonitrile