Sodium Bicarbonate → HCID 178502658, compound

HRID 904867Notes

Reaction equation

HRID 904867 reaction equation
[C:1]([CH2:6][N:7]1[C:11]([SH:12])=[N:10][N:9]=[N:8]1)([C:3]([OH:5])=[O:4])=O.Cl.[CH3:14][O:15][NH2:16].C(=O)(O)[O-].[Na+]>O>[C:3]([C:1](=[N:16][O:15][CH3:14])[CH2:6][N:7]1[C:11]([SH:12])=[N:10][N:9]=[N:8]1)([OH:5])=[O:4]

Participants

5

Reactant 3

HCID 516892Sodium BicarbonateHCID 521874O-Methylhydroxylamine hydrochlorideHCID 178526005HCID 178526005, compound

Product 1

HCID 178502658HCID 178502658, compoundYield 85.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 1-oxalomethyl-1H-tetrazole-5-thiol (1.09 g) and methoxyamine hydrochloride (0.47 g) in water (15 ml) was adjusted to pH 6.5 with sodium bicarbonate and stirred at room temperature for 2 hours. After washing with ethyl acetate, the aqueous solution was adjusted to pH 1.8 with 10% hydrochloric acid, extracted with ethyl acetate, dried over magnesium sulfate and evaporated to give 1-(2-carboxy-2-methoxyiminoethyl)-1H-tetrazole-5-thiol (1.05 g), mp 84° to 86° C.

Workup

  1. washAfter washing with ethyl acetate
  2. extractionextracted with ethyl acetate
  3. dry with materialdried over magnesium sulfate
  4. customevaporated

Sources & evidence

ORD record
ord-41f4381c4958476cb0df20ccc7d908e2
Source dataset
uspto-grants-1983_12
Patent number
US04420477

Reaction notes

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