Hydrochloric Acid → HCID 13200167, compound

HRID 905033Notes

Reaction equation

HRID 905033 reaction equation
[C:1]([CH2:9][N:10]1[CH2:15][CH2:14][N:13]([N:16]([CH2:19][C:20]#[N:21])[N:17]=[O:18])[CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:22]>CO>[ClH:22].[ClH:22].[C:1]([CH2:9][N:10]1[CH2:11][CH2:12][N:13]([N+:16]2[N-:17][O:18][C:20](=[NH:21])[CH:19]=2)[CH2:14][CH2:15]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20476827HCID 20476827, compound

Product 1

HCID 13200167HCID 13200167, compoundYield 81.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The resulting 4-(benzoylmethyl)-1-(N-nitrosocyanomethylamino)piperazine was dissolved in 10 ml of methanol. In the solution was added 12 ml of 10% methanolic hydrochloric acid, and the mixture was reacted at 5° C. overnight. The reaction mixture was concentrated under reduced pressure, and the residue was recrystallized from methanol-ether to give 1.8 g (yield 81.8%) of 3-[4- (benzoylmethyl)piperazin-1-yl]sydnonimine dihydrochloride having a melting point of 182° to 184° C. (decomp.).

Workup

  1. customthe mixture was reacted at 5° C. overnight
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customthe residue was recrystallized from methanol-ether

Sources & evidence

ORD record
ord-f68742a90c7148d982516acdbf27f4ed
Source dataset
uspto-grants-1983_12
Patent number
US04421754

Reaction notes

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