Hydrochloric Acid → HCID 15916372, compound

HRID 905048Notes

Reaction equation

HRID 905048 reaction equation
[ClH:1].[F:2][CH2:3][CH:4]([NH:18]C(OC(C)(C)C)=O)[CH2:5][CH2:6][CH:7]([NH:10]C(OC(C)(C)C)=O)[C:8]#[CH:9]>CCOCC>[ClH:1].[ClH:1].[F:2][CH2:3][CH:4]([NH2:18])[CH2:5][CH2:6][CH:7]([NH2:10])[C:8]#[CH:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15916370HCID 15916370, compound

Product 1

HCID 15916372HCID 15916372, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A saturated solution of dry hydrogen chloride in dry ether (10 ml) is added to 1-fluoro-2,5-di-(N-tert.butoxycarbonylamino)-6-heptyne obtained as in Step D above (1 mmole) and left overnight at room temperature. The dichlorohydride which forms as crystals is filtered, washed with ether, and dried to give the title compound (0.21 g).

Workup

  1. customobtained as in Step D above (1 mmole)
  2. filtrationis filtered
  3. washwashed with ether
  4. customdried

Sources & evidence

ORD record
ord-b6a2dcc9d4754c83ad3eaf65f83216d3
Source dataset
uspto-grants-1983_12
Patent number
US04421768

Reaction notes

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