Hydrochloric Acid → HCID 54085372, compound

HRID 905050Notes

Reaction equation

HRID 905050 reaction equation
C(OC([NH:8][CH:9]([C:15]([C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=1)=[CH:16][F:17])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=O)(C)(C)C.Cl>CCOCC>[NH2:8][CH:9]([C:15]([C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=1)=[CH:16][F:17])[C:10]([O:12][CH2:13][CH3:14])=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54552195HCID 54552195, compound

Product 1

HCID 54085372HCID 54085372, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of ethyl 2-tert-butoxycarbonylamino-3-(3'methoxyphenyl)-4-fluoro-3-butenoate (218 mg) in ether (10 ml) saturated with dry HCl is left overnight by which time colorless needles crystallize. These are collected and dried to afford pure recemic ethyl 2-amino-3-(3'-methoxyphenyl)-4-fluoro-3-butenoate (150 mg): colorless needles, m.p. 141°-142°:

Workup

  1. customcrystallize
  2. customThese are collected
  3. customdried

Sources & evidence

ORD record
ord-d0fbd0457dd84d1aac261dd402d9f126
Source dataset
uspto-grants-1983_12
Patent number
US04421767

Reaction notes

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