Hydrochloric Acid → HCID 53684458, compound

HRID 905129Notes

Reaction equation

HRID 905129 reaction equation
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([O:17][CH3:18])=[C:8]([CH:10]=[CH:11][C:12]([O:14]CC)=[O:13])[CH:9]=1)(=[O:3])[CH3:2].[OH-].[Na+].Cl>CO>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([O:17][CH3:18])=[C:8]([CH:10]=[CH:11][C:12]([OH:14])=[O:13])[CH:9]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54349136HCID 54349136, compound

Product 1

HCID 53684458HCID 53684458, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

24 g (0.08 mole) of the ester obtained in step (b) are dissolved in 250 ml of methanol and 50 ml of sodium hydroxide at 400 g/l. After the reaction mixture is heated for 2 hours under reflux, it is left to cool then acidified with 5 N hydrochloric acid. The expected product is left to precipitate and, after filtration, is washed with water then with ethanol and finally with isopropyl ether. 13.6 g of the desired product are obtained. m.p.=203° C.

Workup

  1. temperatureAfter the reaction mixture is heated for 2 hours
  2. temperatureunder reflux
  3. waitit is left
  4. temperatureto cool

Sources & evidence

ORD record
ord-10634768a32a472caead4adf41ddb42f
Source dataset
uspto-grants-1983_12
Patent number
US04421927

Reaction notes

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