Sodium Sulfite → HCID 20475748, compound

HRID 905243Notes

Reaction equation

HRID 905243 reaction equation
C(S[C:9]1[N:14]=[C:13]([CH3:15])[C:12]([Br:16])=[C:11]([CH3:17])[N:10]=1)C1C=CC=CC=1.Cl[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25](OO)=O)[CH:20]=1.[O-:29][S:30]([O-:32])=O.[Na+].[Na+]>ClCCl>[CH2:25]([S:30]([C:9]1[N:14]=[C:13]([CH3:15])[C:12]([Br:16])=[C:11]([CH3:17])[N:10]=1)(=[O:32])=[O:29])[C:21]1[CH:22]=[CH:23][CH:24]=[CH:19][CH:20]=1

Participants

5

Reactant 3

HCID 24437Sodium SulfiteHCID 70297m-Chloroperbenzoic acidHCID 20475694HCID 20475694, compound

Product 1

HCID 20475748HCID 20475748, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 2-benzylthio-4,6-dimethyl-5-bromopyrimidine (5 mmol) and 85% m-chloroperbenzoic acid (15.9 mmol) in dichloromethane (100 ml) was left at room temperature for 3 days. The solution was then shaken with saturated Na2SO3 aq. (3×15 ml), saturated NaCHO3 aq. (3×10 ml) and the dried MgSO4 solution evaporated to leave the sulfone; yield 94%, m.p. 138°-139° C. (iPrOH). 1H NMR (TFA): δ2.83 (Me), 4.93 (CH2), 7.33 (Ph).

Workup

  1. customthe dried MgSO4 solution evaporated

Sources & evidence

ORD record
ord-5edbabfb9e2e4c6f824adc7a160d1aab
Source dataset
uspto-grants-1983_12
Patent number
US04423047

Reaction notes

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