1,2,4-Butanetriol → HCID 20476161, compound

HRID 905264Notes

Reaction equation

HRID 905264 reaction equation
[CH2:1]([OH:7])[CH:2]([OH:6])[CH2:3][CH2:4][OH:5].[CH2:8]([CH:11]([CH2:15][CH2:16][CH3:17])[C:12](Cl)=[O:13])[CH2:9][CH3:10]>N1C=CC=CC=1>[CH2:8]([CH:11]([CH2:15][CH2:16][CH3:17])[C:12]([O:7][CH2:1][CH:2]([O:6][C:12](=[O:13])[CH:11]([CH2:15][CH2:16][CH3:17])[CH2:8][CH2:9][CH3:10])[CH2:3][CH2:4][O:5][C:12](=[O:13])[CH:11]([CH2:15][CH2:16][CH3:17])[CH2:8][CH2:9][CH3:10])=[O:13])[CH2:9][CH3:10]

Participants

4

Reactant 2

HCID 183021,2,4-ButanetriolHCID 762402-Propylvaleryl chloride

Product 1

HCID 20476161HCID 20476161, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Into a perfectly clean and dry flask were introduced 106.1 g (1 mol) of rectified 1,2,4-butanetriol and 1600 ml of anhydrous pyridine. While stirring, 507.4 g (3.12 mols) of di-n-propylacetyl chloride were added in 60 to 90 minutes care being taken to maintain the temperature below 30° C. The reaction medium was then stirred at room-temperature for 72 hours. The subsequent operations of purification were identical to those carried out in the foregoing Example 13.

Workup

  1. customInto a perfectly clean and dry flask
  2. temperatureto maintain the temperature below 30° C
  3. stirringThe reaction medium was then stirred at room-temperature for 72 hours
  4. customThe subsequent operations of purification

Sources & evidence

ORD record
ord-b5e9eb9ed850480bb1fbcf932bd916d9
Source dataset
uspto-grants-1983_12
Patent number
US04423071

Reaction notes

Loading…