反应详情

To a solution of 5-bromo-3-(3-trimethylsilanyl-prop-1-ynyl)-pyrazin-2-ylamine (1.66 g, 66% purity, 5.84 mmol) in 25 mL of THF was added a solution of tBuOK in THF (1M, 11.7 mL, 11.7 mmol) slowly at RT. The reaction mixture was heated to reflux for 2 days, then cooled to RT, diluted with EtOAc, quenched with H2O, filtered through a pad of celite, and washed with H2O and EtOAc. The organic layer was separated, washed with H2O and brine, dried (MgSO4), and concentrated to give 598 mg of 2-bromo-6-methyl-5H-pyrrolo[2,3-b]pyrazine as a brown solid (48% yield).

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 2 days
3. customquenched with H2O
4. filtrationfiltered through a pad of celite
5. washwashed with H2O and EtOAc
6. customThe organic layer was separated
7. washwashed with H2O and brine
8. dry with materialdried (MgSO4)
9. concentrationconcentrated