反应详情

1.1 eq of aqueous NaOH (1 M solution) was added to a solution of methyl 4-bromobenzoate in THF (0.5 M) and the reaction allowed to stir at RT overnight. THF was removed in vacuo and aqueous HCl (6M) was added dropwise to the basic solution at 0° C. to adjust the pH to pH 2. The resultant aqueous mixture was extracted with EtOAc (3×) and then the combined organics were washed with brine, dried over Na2SO4, filtered and the solvent evaporated in vacuo. The title compound was obtained in quantitative yield; MS (ES+) m/z 201 (M+H)+, m/z 203 (M+H)+

1. customTHF was removed in vacuo and aqueous HCl (6M)
2. additionwas added dropwise to the basic solution at 0° C.
3. extractionThe resultant aqueous mixture was extracted with EtOAc (3×)
4. washthe combined organics were washed with brine
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. customthe solvent evaporated in vacuo