Methanol → Tert-butyl 9-amino-2,2-difluoro-6,7,8,9-tetrahydro-[1,3]dioxolo[4,5-h][1]benzazepine-5-carboxylate
Reaction equation
[C:1]([O:2][C:3]([N:4]1[c:5]2[c:6]([cH:7][c:8]3[c:14]([cH:15]2)[O:13][C:10]([F:11])([F:12])[O:9]3)[CH:16]([OH:17])[CH2:18][CH2:19][CH2:20]1)=[O:21])([CH3:22])([CH3:23])[CH3:24].[C:36]([CH3:37])([CH3:38])([CH3:39])[O:40][C:41](=[O:42])[N:43]1[CH2:44][CH2:45][CH2:46][CH:47]([N:59]=[N+:60]=[N-:61])[c:48]2[cH:49][c:50]3[c:54]([cH:55][c:56]21)[O:53][C:52]([F:57])([F:58])[O:51]3.[CH2:25]1[CH2:26][CH2:27][C:28]2=[N:33][CH2:32][CH2:31][CH2:30][N:29]2[CH2:34][CH2:35]1.[CH3:62][c:63]1[cH:64][cH:65][cH:66][cH:67][cH:68]1.[CH3:69][OH:70]>>[C:36]([CH3:37])([CH3:38])([CH3:39])[O:40][C:41](=[O:42])[N:43]1[CH2:44][CH2:45][CH2:46][CH:47]([NH2:59])[c:48]2[cH:49][c:50]3[c:54]([cH:55][c:56]21)[O:53][C:52]([F:57])([F:58])[O:51]3Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-6d8881ba50914ff49cd8c3bed5b9a26c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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