5,8-Dibromo-(1,2,4)triazolo(1,5-a)pyrazine → HCID 57963930, compound

HRID 906223Notes

Reaction equation

HRID 906223 reaction equation
[CH:1]([N:4]1[CH2:9][C@H:8]2[CH2:10][C@@H:5]1[CH2:6][N:7]2[C:11]1[CH:17]=[CH:16][C:14]([NH2:15])=[CH:13][CH:12]=1)([CH3:3])[CH3:2].[Br:18][C:19]1[N:24]2[N:25]=[CH:26][N:27]=[C:23]2[C:22](Br)=[N:21][CH:20]=1>C(N(CC)CC)C>[Br:18][C:19]1[N:24]2[N:25]=[CH:26][N:27]=[C:23]2[C:22]([NH:15][C:14]2[CH:13]=[CH:12][C:11]([N:7]3[CH2:6][C@H:5]4[CH2:10][C@@H:8]3[CH2:9][N:4]4[CH:1]([CH3:3])[CH3:2])=[CH:17][CH:16]=2)=[N:21][CH:20]=1

Participants

4

Reactant 2

HCID 497580225,8-Dibromo-(1,2,4)triazolo(1,5-a)pyrazineHCID 57963923HCID 57963923, compound

Product 1

HCID 57963930HCID 57963930, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

To the solution obtained from step 2 is added 5,8-dibromo[1,2,4]triazolo[1,5-a]-pyrazine (1.6 g; 5.8 mmol) and triethylamine (3.4 mL). The resulting mixture was heated at reflux for 70 h, after which the reactor contents were cooled down and filtered to remove solids. The filter cake was washed with 2-MeTHF (2×5 mL) and the filtrate used as such in the next step.

Workup

  1. temperatureThe resulting mixture was heated
  2. temperatureat reflux for 70 h
  3. temperatureafter which the reactor contents were cooled down
  4. filtrationfiltered
  5. customto remove solids
  6. washThe filter cake was washed with 2-MeTHF (2×5 mL)

Sources & evidence

ORD record
ord-cffa467fa20e4407a4673ea114def9ba
Source dataset
uspto-grants-2011_09
Patent number
US08012983B2

Reaction notes

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