2-Bromobenzonitrile → 1,1-Dimethylethyl 4-[(2-cyanophenyl)amino]-1-piperidinecarboxylate

HRID 906352Notes

Reaction equation

HRID 906352 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1.Br[C:16]1[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=1[C:18]#[N:19].C(C1C=C(NC2CCN(C(OC(C)(C)C)=O)CC2)C=CC=1)#N>>[C:18]([C:17]1[CH:20]=[CH:21][CH:22]=[CH:23][C:16]=1[NH:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:6][CH2:7]1)#[N:19]

Participants

4

Reactant 3

HCID 162722-BromobenzonitrileHCID 12682914-Amino-1-Boc-piperidineHCID 252237961,1-Dimethylethyl 4-[(3-cyanophenyl)amino]-1-piperidinecarboxylate

Product 1

HCID 576995121,1-Dimethylethyl 4-[(2-cyanophenyl)amino]-1-piperidinecarboxylate

Procedure

The title compound was prepared from 1,1-dimethylethyl 4-amino-1-piperidinecarboxylate and 2-bromobenzonitrile using a method similar to that described for D5 in Description 5.

Sources & evidence

ORD record
ord-993fdb532b8e4fcd81ba4f211bf7de53
Source dataset
uspto-grants-2011_09
Patent number
US08012981B2

Reaction notes

Loading…