Methanol → HCID 86640966, compound

HRID 906412Notes

Reaction equation

HRID 906412 reaction equation
C([O:4][CH2:5][CH2:6][CH2:7][N:8]1[CH:17]=[C:16]([CH:18]=[O:19])[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:20]3[CH:25]=[C:24]([C:26](=[O:31])[NH:27][CH:28]4[CH2:30][CH2:29]4)[CH:23]=[C:22]([F:32])[C:21]=3[CH3:33])[CH:14]=2)[C:9]1=[O:34])(=O)C.CO.C(=O)([O-])[O-].[K+].[K+]>O>[CH:28]1([NH:27][C:26](=[O:31])[C:24]2[CH:25]=[C:20]([C:13]3[CH:14]=[C:15]4[C:10](=[CH:11][CH:12]=3)[C:9](=[O:34])[N:8]([CH2:7][CH2:6][CH2:5][OH:4])[CH:17]=[C:16]4[CH:18]=[O:19])[C:21]([CH3:33])=[C:22]([F:32])[CH:23]=2)[CH2:30][CH2:29]1

Participants

5

Reactant 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 86640965HCID 86640965, compound

Product 1

HCID 86640966HCID 86640966, compoundYield 98.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3-(6-(5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl)-4-formyl-1-oxoisoquinolin-2(1H)-yl)propyl acetate (Example 10d, 0.75 g) was treated with methanol (15 mL) and potassium carbonate (0.25 g) and the resulting mixture was stirred at room temperature for 30 min, diluted with water and extracted with ethyl acetate. The organic layer was dried (MgSO4), filtered and evaporated to afford the subtitle compound (0.67 g).

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic layer was dried (MgSO4)
  3. filtrationfiltered
  4. customevaporated

Sources & evidence

ORD record
ord-d2db8601d4334fe9aa9a603237e06ecc
Source dataset
uspto-grants-2011_09
Patent number
US08012980B2

Reaction notes

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