反应详情

To a solution of N-(methoxymethyl)-N-(phenylmethyl)-N-(trimethylsilyl)methylamine (48.3 g, 204 mmol) and (E)-3-(3,4-difluoro-phenyl)-acrylic acid (15 g, 81.5 mmol) in THF (200 mL) was added trifluoroacetic acid (0.312 mL, 0.0041 mol) at 0° C. The mixture was gradually warmed to room temperature and stirred overnight. It was then concentrated in vaccuo and the residue was diluted with n-heptane (500 mL) followed by vigorous stirring for 1 hour. The resulted white precipitation was collected and washed with heptane affording 26 g (100%) of the title compound as a white solid. MS m/e: 318.1 (M+H+).

1. concentrationIt was then concentrated in vaccuo
2. additionthe residue was diluted with n-heptane (500 mL)
3. stirringby vigorous stirring for 1 hour
4. customThe resulted white precipitation
5. customwas collected
6. washwashed with heptane affording 26 g (100%) of the title compound as a white solid