Lithium Carbonate → HCID 59273030, compound

HRID 907024Notes

Reaction equation

HRID 907024 reaction equation
[CH:1]1([C@:4]2([OH:12])[CH2:8][CH2:7][NH:6][C@H:5]2[CH:9]([CH3:11])C)[CH2:3]C1.F[C:14]1[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([C:22]([F:25])([F:24])[F:23])[CH:15]=1.C(=O)([O-])[O-].[Li+].[Li+]>>[CH2:9]([C@H:5]1[C@@:4]([CH2:1][CH3:3])([OH:12])[CH2:8][CH2:7][N:6]1[C:14]1[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([C:22]([F:23])([F:25])[F:24])[CH:15]=1)[CH3:11]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 6050854-Fluoro-2-(trifluoromethyl)benzonitrileHCID 59273011(2S,3R)-3-cyclopropyl-2-isopropylpyrrolidin-3-ol

Product 1

HCID 59273030HCID 59273030, compound

Procedure

By an operation in the same manner as in Example 1 and using (2S,3S)-2,3-diethylpyrrolidin-3-ol 0.5 oxalate (193 mg), 4-fluoro-2-(trifluoromethyl)benzonitrile (364 mg) and lithium carbonate (221 mg), the title compound was obtained as pale-yellow oil (yield: 219 mg, yield: 82%).

Sources & evidence

ORD record
ord-7803e5faaa8c42d2991b45012a4293b7
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

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