Hydrochloric Acid → HCID 131729161, compound

HRID 907249Notes

Reaction equation

HRID 907249 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH3:44])=[C:11]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[C:19](=[O:23])[N:18]([CH2:24][C:25]3[CH:30]=[CH:29][C:28]([C:31]5[CH2:32][CH2:33][N:34](C(OC(C)(C)C)=O)[CH2:35][CH:36]=5)=[CH:27][CH:26]=3)[CH:17]=[CH:16]4)[CH:12]=2)=[O:6])[CH2:3][CH2:2]1.[ClH:45]>CO.O1CCOCC1>[ClH:45].[CH:1]1([NH:4][C:5](=[O:6])[C:7]2[CH:8]=[CH:9][C:10]([CH3:44])=[C:11]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[C:19](=[O:23])[N:18]([CH2:24][C:25]3[CH:30]=[CH:29][C:28]([C:31]5[CH2:32][CH2:33][NH:34][CH2:35][CH:36]=5)=[CH:27][CH:26]=3)[CH:17]=[CH:16]4)[CH:12]=2)[CH2:2][CH2:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 25020512HCID 25020512, compound

Product 1

HCID 131729161HCID 131729161, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of Example 6 step (iii) (0.2 g) in methanol (10 mL) was treated with 4.0M HCl in 1,4-dioxane (10 mL) and the solution stirred at room temperature for 2 hours. The volatiles were then removed under reduced pressure and the residue triturated with diethyl ether to give the product, after filtration as a solid (80 mg).

Workup

  1. customThe volatiles were then removed under reduced pressure
  2. customthe residue triturated with diethyl ether
  3. customto give the product
  4. filtrationafter filtration as a solid (80 mg)

Sources & evidence

ORD record
ord-cd547649386d4e15868a04600b6bbc1a
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

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