Methylamine → N-Cyclopropyl-4-methyl-3-(2-(4-(2-(methylamino)ethoxy)benzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)benzamide

HRID 907271Notes

Reaction equation

HRID 907271 reaction equation
Cl[CH2:2][CH2:3][O:4][C:5]1[CH:35]=[CH:34][C:8]([CH2:9][N:10]2[CH:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:20]4[CH:21]=[C:22]([CH:29]=[CH:30][C:31]=4[CH3:32])[C:23]([NH:25][CH:26]4[CH2:28][CH2:27]4)=[O:24])[CH:16]=3)[C:11]2=[O:33])=[CH:7][CH:6]=1.[CH3:36][NH2:37]>>[CH:26]1([NH:25][C:23](=[O:24])[C:22]2[CH:29]=[CH:30][C:31]([CH3:32])=[C:20]([C:15]3[CH:16]=[C:17]4[C:12](=[CH:13][CH:14]=3)[C:11](=[O:33])[N:10]([CH2:9][C:8]3[CH:34]=[CH:35][C:5]([O:4][CH2:3][CH2:2][NH:37][CH3:36])=[CH:6][CH:7]=3)[CH:19]=[CH:18]4)[CH:21]=2)[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 575518303-(2-(4-(2-Chloroethoxy)benzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

Product 1

HCID 57551794N-Cyclopropyl-4-methyl-3-(2-(4-(2-(methylamino)ethoxy)benzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)benzamide

Procedure

The title compound was prepared according to the method of Example 32 step (iii) using the product of Example 32 step (ii) and methylamine.

Sources & evidence

ORD record
ord-6164e54ed82d43f894557949fc43a586
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

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