反应详情

To a mixture of the product of step iii) (0.1 g), 4-(N-pyrrolidin-1-yl)piperidine (0.037 g) and N,N-diisopropylethylamine (0.25 mL) in tetrahydrofuran (10 mL) was added HATU (0.17 g) and then stirred at room temperature for 3 hours. The reaction mixture was then concentrated to dryness and the crude product purified by HPLC to afford the title compound as a solid (0.07 g).

1. concentrationThe reaction mixture was then concentrated to dryness
2. customthe crude product purified by HPLC