Hydrochloric Acid → HCID 57551750, compound

HRID 907352Notes

Reaction equation

HRID 907352 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH3:38])=[C:11]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[C:19](=[O:23])[N:18]([CH2:24][CH:25]3[CH2:30][CH2:29][N:28](C(OC(C)(C)C)=O)[CH2:27][CH2:26]3)[CH:17]=[CH:16]4)[CH:12]=2)=[O:6])[CH2:3][CH2:2]1.Cl>CO.O1CCOCC1>[CH:1]1([NH:4][C:5](=[O:6])[C:7]2[CH:8]=[CH:9][C:10]([CH3:38])=[C:11]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[C:19](=[O:23])[N:18]([CH2:24][CH:25]3[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)[CH:17]=[CH:16]4)[CH:12]=2)[CH2:2][CH2:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57551799HCID 57551799, compound

Product 1

HCID 57551750HCID 57551750, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of the product of step i) (170 mg) in methanol (5 mL) was added 4M HCl in 1,4-dioxane (5 mL). The solution was stirred at room temperature for 2 hours. The volatiles were removed under vacuum and the residue was purified by HPLC to yield the title compound as a solid (25 mg).

Workup

  1. customThe volatiles were removed under vacuum
  2. customthe residue was purified by HPLC

Sources & evidence

ORD record
ord-880b563dbf234437961835812c1e05b6
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

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