Lithium Hydroxide → HCID 67393125, compound

HRID 907368Notes

Reaction equation

HRID 907368 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1/[CH:7]=[CH:8]/[C:9]1[CH:18]=[CH:17][C:12]([C:13]([O:15]C)=[O:14])=[CH:11][CH:10]=1.[OH-].[Li+:20]>CO>[Li+:20].[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1/[CH:7]=[CH:8]/[C:9]1[CH:10]=[CH:11][C:12]([C:13]([O-:15])=[O:14])=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 67392650HCID 67392650, compound

Product 1

HCID 67393125HCID 67393125, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

Methyl 4-[(E)-2-(1-methyl-1H-pyrrol-2-yl)ethenyl]benzoate (40 mg, 0.166 mmol; see step (i) above) was suspended in a mixture of methanol (1 mL) and lithium hydroxide solution (16 mg of LiOH in water 2 mL). The reaction mixture was heated at 60° C. overnight with stirring. This solution was freeze-dried and the title compound used in the next step without further purification.

Workup

  1. customThis solution was freeze-dried
  2. customthe title compound used in the next step without further purification

Sources & evidence

ORD record
ord-a5f47186ec2146cfa354c6e67091b6ab
Source dataset
uspto-grants-2011_09
Patent number
US08012967B2

Reaction notes

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