p-Toluidine → HCID 968627, compound

HRID 907437Notes

Reaction equation

HRID 907437 reaction equation
CO[C:3](=[O:13])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1.[NH2:14][C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=1.[H-].[Na+]>CS(C)=O>[CH3:12][O:11][C:8]1[CH:7]=[CH:6][C:5]([CH2:4][C:3]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)=[O:13])=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 7813p-ToluidineHCID 24758Sodium hydrideHCID 90266Methyl 4-methoxyphenylacetate

Product 1

HCID 968627HCID 968627, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

(4-methoxy-phenyl)-acetic acid methyl ester Compound 22a was reacted with p-toluidine and sodium hydride in DMSO at room temperature to provide 2-(4-methoxy-phenyl)-N-p-tolyl-acetamide Compound 22b.

Sources & evidence

ORD record
ord-a708b56966c44261b65c21f92f63930b
Source dataset
uspto-grants-2011_09
Patent number
US08013153B2

Reaction notes

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