Ethylamine → HCID 4349058, compound

HRID 907439Notes

Reaction equation

HRID 907439 reaction equation
CO[C:3](=[O:13])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1.[CH2:14]([NH2:16])[CH3:15].[H-].[Na+]>CS(C)=O>[CH2:14]([NH:16][C:3](=[O:13])[CH2:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH3:12])=[CH:9][CH:10]=1)[CH3:15]

Participants

5

Reactant 3

HCID 6341EthylamineHCID 24758Sodium hydrideHCID 90266Methyl 4-methoxyphenylacetate

Product 1

HCID 4349058HCID 4349058, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Using the procedure for Example 22, (4-methoxy-phenyl)-acetic acid methyl ester Compound 22a was reacted with ethylamine and sodium hydride in DMSO at room temperature to provide N-ethyl-2-(4-methoxy-phenyl)-acetamide Compound 24a. Compound 24a was reacted with borotribromide in dichloromethane to yield N-ethyl-2-(4-hydroxy-phenyl)-acetamide Compound 24b.

Sources & evidence

ORD record
ord-c461237bf6e1408885153fa78ef85f67
Source dataset
uspto-grants-2011_09
Patent number
US08013153B2

Reaction notes

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