反应详情

温度

40 °C

To a solution of 1H-imidazole-2-carbaldehyde (240 mg, 2.4 mmol) and potassium carbonate (662 mg, 4.8 mmol) in acetonitrile (5 mL) at 0° C. was added dropwise (bromomethyl)benzene (493 mg, 2.88 mmol). The mixture was stirred at 40° C. for 4 hr. Then the mixture was filtrated, evaporated to remove the acetonitrile from the filtrate, added EtOAc to extract the residues, and washed the extract with brine and water. The organic layer was dried with anhydrous Na2SO4, concentrated, and chromatographed on a silica gel column (EtOAc:hexane=1:9) to obtain the title compound (430 mg, yield 95%). LC-MS (ESI) m/z: 187 (M+1)+.

1. filtrationThen the mixture was filtrated
2. customevaporated
3. customto remove the acetonitrile from the filtrate
4. additionadded EtOAc
5. extractionto extract the residues
6. washwashed the
7. extractionextract with brine and water
8. dry with materialThe organic layer was dried with anhydrous Na2SO4
9. concentrationconcentrated
10. customchromatographed on a silica gel column (EtOAc:hexane=1:9)