反应详情

A mixture of 5-(2-chloro-ethyl)-[1,3,4]thiadiazol-2-ylamine (54a) (2.5 g, 15.3 mmol), morpholine (2.67 g, 30 mmol) and sodium iodide (0.15 g) is heated with stirring in toluene at 80° C. After adding triethylamine (2.13 ml, 15.3 mmol) heating is continued for an additional 4 hours. The solvent is removed and the residue is partitioned between water (pH 13) and n-butanol. The organic extract is dried (MgSO4) and the solid is removed to afford the titled compound as a yellow solid.

1. temperatureis heated
2. temperatureheating
3. customThe solvent is removed
4. customthe residue is partitioned between water (pH 13) and n-butanol
5. extractionThe organic extract
6. dry with materialis dried (MgSO4)
7. customthe solid is removed