反应详情

2-Bromoacetophenone (17.29 g, 87 mmol) and NaHCO3 (8.03 g, 96 mmol) were added to a solution of methyl 2-amino-5-bromoisonicotinate (20.07 g, 87 mmol) in methanol (240 ml), and the mixture was heated to reflux (5 h). After cooling to r.t., water (75 ml) was added, and the brown suspension was stirred (15 min) and filtered. The precipitate was washed with a small amount of methanol. The title compound (10.11 g, 35%) was dried under vacuum and was used in the next step without further purification.

1. temperaturethe mixture was heated
2. temperatureto reflux (5 h)
3. filtrationfiltered
4. washThe precipitate was washed with a small amount of methanol
5. dry with materialThe title compound (10.11 g, 35%) was dried under vacuum
6. customwas used in the next step without further purification