Hydrochloric Acid → HCID 58446922, compound

HRID 908231Notes

Reaction equation

HRID 908231 reaction equation
[OH-].[Na+].C([O:5][C:6]([C:8]1[N:9]([CH3:19])[N:10]=[CH:11][C:12]=1[C:13]([N:15]1[CH2:18][CH2:17][CH2:16]1)=[O:14])=[O:7])C.Cl.[Na+].[Cl-]>C1COCC1>[N:15]1([C:13]([C:12]2[CH:11]=[N:10][N:9]([CH3:19])[C:8]=2[C:6]([OH:7])=[O:5])=[O:14])[CH2:18][CH2:17][CH2:16]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 67041800ethyl 4-(azetidine-1-carbonyl)-1-methyl-1H-pyrazole-5-carboxylate

Product 1

HCID 58446922HCID 58446922, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

NaOH (1N, 10 ml) was added to a solution of 4-(azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester (1.32 g, 5.0 mmol) in THF (50 ml), and the mixture was stirred at r.t. (3.5 h). The mixture was neutralized by addition of HCl (1N, 10 ml). The mixture was evaporated under vacuum and the title compound, containing theoretically 2 equiv. of NaCl, (1.72 g, 99%) was used in Step 6 without further purification. MS (m/e)=210.2 [M+H+].

Workup

  1. customThe mixture was evaporated under vacuum

Sources & evidence

ORD record
ord-8549ca19a572413c87c2426f9bcb4212
Source dataset
uspto-grants-2011_09
Patent number
US08017604B2

Reaction notes

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