Hydrochloric Acid → HCID 178510551, compound

HRID 908250Notes

Reaction equation

HRID 908250 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[NH:25][C:12]2=[N:13][CH:14]=[C:15]([C:17]([NH:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[O:18])[CH:16]=[C:11]2[N:10]=1)(C)(C)C.Cl>O1CCOCC1>[NH2:7][CH2:8][C:9]1[NH:25][C:12]2=[N:13][CH:14]=[C:15]([C:17]([NH:19][CH2:20][C:21]([F:24])([F:22])[F:23])=[O:18])[CH:16]=[C:11]2[N:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178453116tert-butyl[(6-{[(2,2,2-trifluoroethyl)amino]carbonyl}-3H-imidazo[4,5-b]pyridin-2-yl)methyl]carbamate

Product 1

HCID 178510551HCID 178510551, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-butyl[(6-{[(2,2,2-trifluoroethyl)amino]carbonyl}-3H-imidazo[4,5-b]pyridin-2-yl)methyl]carbamate (0.657 g, 1.76 mmol) was treated with 4N HCl in dioxane (30 ml). The reaction mixture was stirred at room temperature overnight, concentrated under reduced pressure and co-evaporated with EtOAc twice to give title compound. This crude product was used in the next step without further purification.

Workup

  1. concentrationconcentrated under reduced pressure and co-evaporated with EtOAc twice

Sources & evidence

ORD record
ord-b09169e585c54fdea3a211bc8fe6c9d1
Source dataset
uspto-grants-2011_09
Patent number
US08017605B2

Reaction notes

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